Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica.
نویسندگان
چکیده
Bruceantin, purified from an Ethiopian plant used to treat dysentery, killed Entamoeba histolytica in vitro (IC50 [the concentration of drug which decreased the number of colonies to half that of controls] = 0.018 microgram/ml). Six related quassinoids of 17 tested were also amoebicidal. No relationship between quassinoid structure and amoebicidal activity was apparent.
منابع مشابه
Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium.
BACKGROUND The search for new antimalarial drugs has become increasingly urgent due to plasmodial resistance to existing drugs. As part of this global effort, the present study aimed at evaluating the antimalarial activity of two traditionally used medicinal plants against the disease. METHODS Acute toxicity and four-day suppressive effects of aqueous, methanol and chloroform extracts of the ...
متن کاملAntibacterial activities of selected medicinal plants in traditional treatment of human wounds in Ethiopia.
OBJECTIVE To evaluate the activity of selected Ethiopian medicinal plants traditionally used for wound treatment against wound-causing bacteria. METHODS Samples of medicinal plants (Achyranthes aspera, Brucea antidysenterica, Datura stramonium, Croton macrostachyus, Acokanthera schimperi, Phytolacca dodecandra, Millettia ferruginea, and Solanum incanum) were extracted using absolute methanol ...
متن کاملChem. Pharm. Bull. 51(4) 385—389 (2003)
various biological activities, such as antitumor, antimalarial, antifeedant, insecticidal, antiinflammatory, amoebicidal, and herbicidal effects. We are interested in such biologically active compounds and have isolated many quassinoids from plants, such as Brucea antidysenterica, Picrasma ailanthoides, and Brucea javanica. As part of these studies, we investigated the isolation of quassinoids ...
متن کاملAnti-diabetic Potential of Ethanolic Extract of Holarrhena antidysenterica Linn Leaves
The anti-diabetic activity of ethanolic extract of Holarrhena antidysenterica leaves (EEHA) was evaluated against alloxan (100 mg/kg, i.p.) and streptozotocin (STZ) (50 mg/kg, i.p.) induced diabetes in Wistar rats. Oral glucose tolerance test was also performed. The effect was compared with antidiabetic activity of glibenclamide (5 mg/kg, p.o.). In alloxan and STZ induced hyperglycemic rats, a ...
متن کاملChemical Composition and Cytotoxic Activities of Petroleum Ether Fruit Extract of Fruits of Brucea javanica (Simarubaceae)
Purpose: To investigate the chemical composition and antitumor activity of the petroleum ether extract of the dried ripe fruits of Brucea javanica. Methods: The composition of petroleum ether extract was analyzed by gas chromatography/mass spectrometric (GC/MS) and their antitumor activities were determined by MTT assay. Results: GC/MS spectrometry results indicate that the petroleum ether extr...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 22 2 شماره
صفحات -
تاریخ انتشار 1982